UMSL’s Anchor Institution Initiative is working to strengthen the local community by committing to local purchasing, local hiring, and community development. To reach these goals, UMSL has hosted a Vendor Opportunity Fair, partnered with North Tech and SoulFisher ministries for hiring events, and secured a "Great Streets" grant to redevelop a large portion of Natural Bridge Road, creating a more walkable environment. In the wake of the COVID-19 pandemic, the Anchor Institution Initiative has partnered with area economic development agencies to provide information and resources including host a resource webinar for small businesses.

UMSL Colleges of Nursing, Optometry, and Education and the School of Social Work continue to partner and develop projects with area schools, nonprofit organizations and health providers to address educational, health and social service needs in nearby communities.